I would find it odd. Not weird, not bad, just odd. I guess it's because YouTube is a platform that makes me feel closer to the content creators that I don't see them as "unattainable" celebrities, if that makes any sense. If I met a movie start I would go bananas, if I met a YouTube star I'd be kind of "Ah cool". More relaxed. I know millions of people watch YouTube, but no one around me does so I don't imagine it happening.
But all in all, I wouldn't mind. I'm awkward but not mean.